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WTAP Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Brand:  Proteintech 10200-1-AP-20UL

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Product Code. 16886423

  • 1645.54 SEK / 20µL

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Description

Description

Wilms′ tumor (WT) is an embryonal maligcy of the kidney that affects 1 in 10,000 infants and is observed in both sporadic and inherited forms. The Wilms′ tumor protein (WT1) binds the DNA sequence GCGGGGGCG, a recognition element common to the early growth response (Egr) family of Zn2+ finger transcriptional activators, and functions as a transcriptional repressor. WTAP (Wilms tumor 1-associating protein) is a ubiquitously expressed nuclear protein that interacts with WT1 and may be involved in regulating mRNA splicing. WTAP is found in nuclear speckles, where it regulates the G2/M cell cycle transition by binding to the 3′ UTR of cyclin A2, thus enhancing its stability. Additionally, WTAP inhibits expression of WT1 target genes and is able to impair the ability of WT1 to bind DNA. Two isoforms of WTAP exist due to alternative splicing events.
Specifications

Specifications

WTAP
Polyclonal
Unconjugated
WTAP
Female lethal(2)D homolog, hFL(2)D, KIAA0105, WT1 associated protein, WTAP
Rabbit
Antigen Affinity Chromatography
RUO
499020, 60532, 9589
-20°C
Liquid
Immunoprecipitation, Western Blot
0.2 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Q15007, Q9ER69
Wtap
WTAP Fusion Protein Ag0259
20 μL
Primary
Rat, Mouse, Human
Antibody
IgG
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WTAP Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech > 20 μL; Unconjugated

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