ZO-1 Rat anti-Canine, Mouse, Rat, Clone: R26.4C, eBioscience™
Rat Monoclonal Antibody
Brand: Affymetrix eBioscience 14-9776-82
Additional Details : Weight : 0.09500kg
DescriptionPurity: Greater than 90%, as determined by SDS-PAGE. Aggregation: Less than 10%, as determined by HPLC. Filtration: 0.2 μm post-manufacturing filtered. ZO-1 forms complexes with either ZO-2 or ZO-3. In addition, these proteins can also associate with claudin, occludin and F-actin, at tight junction stands, where they provide a linkage between the actin cytoskeleton and the tight junction. ZO-1 expression is significantly reduced in many breast cancer lines. ZO-2 and ZO-3 are ubiquitously expressed within epithelial tight junctions, and unlike ZO-1, which is also expressed at cell junctions of cardiac myocytes, ZO-2 is not expressed in nonepithelial tissue. ZO-1 is a protein located on a cytoplasmic membrane surface of intercellular tight junctions. ZO-1 may be involved in signal transduction at cell-cell junctions. Two transcript variants encoding distinct isoforms have been identified for the ZO-1 gene. Diseases associated with ZO-1 dysfunction include Celiac Disease and Congenital Nephrotic Syndrome.
|PBS with 0.09% sodium azide; pH 7.2|
|DKFZp686M05161, MGC133289, ZO-1|
|Canine, Mouse, Rat|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Frozen), Western Blot|
|21872, 292994, 403752|
For Research Use Only.