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ZO-1 Rat anti-Canine, Mouse, Rat, Clone: R26.4C, eBioscience™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-9776-82

Additional Details : Weight : 0.09500kg

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Product Code. 15557676

  • 2590.00 SEK / 100µg


In stock, ready to ship: 3
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Description

Description

Purity: Greater than 90%, as determined by SDS-PAGE. Aggregation: Less than 10%, as determined by HPLC. Filtration: 0.2 μm post-manufacturing filtered. ZO-1 forms complexes with either ZO-2 or ZO-3. In addition, these proteins can also associate with claudin, occludin and F-actin, at tight junction stands, where they provide a linkage between the actin cytoskeleton and the tight junction. ZO-1 expression is significantly reduced in many breast cancer lines. ZO-2 and ZO-3 are ubiquitously expressed within epithelial tight junctions, and unlike ZO-1, which is also expressed at cell junctions of cardiac myocytes, ZO-2 is not expressed in nonepithelial tissue. ZO-1 is a protein located on a cytoplasmic membrane surface of intercellular tight junctions. ZO-1 may be involved in signal transduction at cell-cell junctions. Two transcript variants encoding distinct isoforms have been identified for the ZO-1 gene. Diseases associated with ZO-1 dysfunction include Celiac Disease and Congenital Nephrotic Syndrome.
Specifications

Specifications

ZO-1
Monoclonal
0.5 mg/mL
PBS with 0.09% sodium azide; pH 7.2
P39447, O97758
DKFZp686M05161, MGC133289, ZO-1
Rat
Affinity chromatography
RUO
Antibody
Monoclonal
Canine, Mouse, Rat
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Frozen), Western Blot
R26.4C
Unconjugated
Tjp1
Liquid
Tjp1
IgG2a, kappa
100 μg
4° C
Primary
21872, 292994, 403752
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For Research Use Only.