Proteomics

Application and Solution Series

Proteomics Application and Solution Series

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Significant events in Proteomics

1838

Proteins were first described by the Dutch chemist Gerardus Johannes Mulder and named by the Swedish chemist Jöns Jacob Berzelius in 1838.. [2]

1926

James B. Sumner discovered that the enzyme urease was a protein, showing that protein have a central role
as enzymes in living organisms.[3]

1949

Insulin is the first protein sequenced by Frederik Sanger. He determines that protein are composed of a linear amino acide sequence[4]

1958

First 3D model showing structure of the myoglobin protein by Sir John Cowdery Kendrew[5]

1960

Radioimmunoassay first described in a scientific paper by Rosalyn Sussman Yalow and Solomon Berson [6]

1971

Peter Perlmann and Eva Engvall at Stockholm University in Sweden, and Anton Schuurs and Bauke van Weemen in the Netherlands independently published papers that synthesized this knowledge into methods to perform EIA/ELISA[7] [8]


  1. P. James (1997). "Protein identification in the post-genome era: the rapid rise of proteomics". Quarterly reviews of biophysics 30 (4): 279–331.
  2. Perrett D (2007). "From 'protein' to the beginnings of clinical proteomics".Proteomics – Clinical Applications 1 (8): 720–38.
  3. Sanger, F, Air, GM, Barrell, BG, Brown, NL, Coulson, AR, Fiddes, CA, Hutchison, CA, Slocombe, PM et al. (Feb 1977). "Nucleotide sequence of bacteriophage phi X174 DNA". Nature 265 (5596): 687–95.
  4. Sanger F (1949). "The terminal peptides of insulin". Biochemical Journal 45 (5): 563–74.
  5. Kendrew J, Bodo G, Dintzis H, Parrish R, Wyckoff H, Phillips D (1958). "A three-dimensional model of the myoglobin molecule obtained by X-ray analysis". Nature 181(4610): 662–66.
  6. YALOW R, BERSON S (1960). "Immunoassay of endogenous plasma insulin in man". J. Clin. Invest. 39 (7): 1157–75.
  7. Engvall E, Perlman P (1971). "Enzyme-linked immunosorbent assay (ELISA). Quantitative assay of immunoglobulin G". Immunochemistry 8 (9): 871–4.
  8. Van Weemen BK, Schuurs AH (1971). "Immunoassay using antigen-enzyme conjugates". FEBS Letters 15 (3): 232–236.

Proteomics in numbers

Proteomics in numbers
Sample preparation

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Kinematica
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Protein characterisation

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Protein detection

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Protein interaction

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