CAS RN 162011-90-7
IUPAC Namn:
4-(4-methanesulfonylphenyl)-3-phenyl-2,5-dihydrofuran-2-one
Synonymer:
rofecoxib vioxx ceoxx
Molekylvikt (g/mol):
314.36
Molekylär sammansättning:
C17H14O4S
InChi Key:
RZJQGNCSTQAWON-UHFFFAOYSA-N
SMILES:
CS(=O)(=O)C1=CC=C(C=C1)C1=C(C(=O)OC1)C1=CC=CC=C1
1
–
4
av
4
Resultat
2
Vioxx, TRC
CAS: 162011-90-7 Molekylformel: C17 H14 O4 S Molekylvikt (g/mol): 314.36 IUPAC-namn: 3-(4-methylsulfonylphenyl)-4-phenyl-2H-furan-5-one LEDER: CS(=O)(=O)c1ccc(cc1)C2=C(C(=O)OC2)c3ccccc3
3
Rofecoxib, MedChemExpress
MedChemExpress Rofecoxib is a potent, specific and orally active COX-2 inhibitor, with IC50s of 26 and 18 nM for human COX-2 in human osteosarcoma cells and Chinese hamster ovary cells, with a 1000-fold selectivity for COX-2 over human COX-1 (IC50 > 50 μM in U937 cells and > 15 μM in Chinese hamster ovary cells).
