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Invitrogen™ Estrogen Receptor alpha (ER alpha) ER Alpha Recombinant Protein Product Code.: 15315806
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Invitrogen™ Estrogen Receptor alpha (ER alpha) ER Alpha Recombinant Protein

Product Code. 15315806
140 μg, Each
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Quantity:
140 μg
Unit Size:
Each
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Product Code. 15315806

Brand: Invitrogen™ A15674

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Description

Includes

One tube of full-length ER Alpha Recombinant Protein.

Recombinant Protein

Estrogen Receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of nuclear receptors. The estrogen receptor is a ligand-activated transcription factor, that when bound to estrogen hormone, induces a conformational change that allows dimerization and binding to estrogen response elements (ERE) in DNA. When bound to EREs, ER can positively or negatively regulate gene transcription through the recruitment of coactivator or corepressor proteins. There are two different forms of the estrogen receptor, alpha and beta, encoded by separate genes (ESR1 and ESR2, respectively). Due to alternative RNA splicing, at least 4 estrogen receptor-alpha isoforms are known to exist (Isoform 1 (66 kDa), Isoform 2 (53 kDa), Isoform 3 (47 kDa), Isoform 4 (35 kDa)). Estrogen receptors are widely expressed in different tissue types and are essential for sexual development and reproductive function. They also play a role in other tissues such as bone. Estrogen receptors are involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number P03372
Concentration See Label
For Use With (Application) Nuclear Receptor Assay
Formulation proprietary buffer with no preservative
Gene ID (Entrez) 2099
Molecular Weight (g/mol) 66.4 kDa
Name Estrogen Receptor alpha (ER alpha) ER Alpha
Quantity 140 μg
Gene Alias DKFZp686N23123; ER; Er alpha; ER36; ERa; ERalpha; ER-alpha; ERalpha protein; ESR; esr 1; Esr1; esr-1; ESRA; Estr; Estra; Estradiol receptor; estrogen nuclear receptor alpha; Estrogen receptor; estrogen receptor 1; estrogen receptor 1 (alpha); estrogen receptor alpha; estrogen receptor alpha c-terminus splice variant 1-2; estrogen receptor alpha E1-E2-1-2; estrogen receptor alpha E1-N2-E2-1-2; estrogen receptor alpha splice variant, CTERP-1; estrogen receptor alpha splice variant, ERalphaDup5; estrogen receptor alpha splice variant, ERalphai45a; estrogen receptor alpha splice variant, ERalphai45bL; estrogen receptor alpha splice variant, ERalphai45bS; estrogen receptor alpha splice variant, ERalphai45c; estrogen receptor alpha splice variant, ERalphai56; estrogen receptor alpha splice variant, ERalphai67; estrogen receptor alpha variant delta 4; estrogen receptor protein; estrogen receptor, alpha; ESTRR; hER-alpha36; I79_001166; Nr3a1; nuclear receptor; nuclear receptor subfamily 3 group A member 1; RNESTROR; RP1-130E4.1; unnamed protein product
Common Name Estrogen Receptor alpha
Gene Symbol ESR1
Conjugate Unconjugated
Species Human
Recombinant Recombinant
Content And Storage -80°C, Avoid Freeze/Thaw Cycles
Expression System Insect cells
Protein Family Growth Factors & Receptors
Protein Form Recombinant, Full Length
Form Liquid
Research Category Signal Transduction
Purity or Quality Grade 80% as determined by a SDS-PAGE gel stained with SimplyBlueTM SafeStain.
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Lot Number2667567A Certificate TypeCertificate of Analysis Date21/02/2025 Product CodeA15674
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