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Invitrogen™ Human PIK3CD/PIK3R1 (p110 delta/p85 alpha), His Tag Recombinant Protein
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Quantity:
1 mg
100 μg
20 μg
Unit Size:
100µg
1mg
20µg
Description
Phosphatidylinositol 3-kinase (PI3K) is composed of a catalytic subunit (p110-delta) and a regulatory subunit (p85-alpha in this case), which are encoded by the PIK3CD and PIK3R1 genes. PI3K phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring. It plays a role in oncogenic transformation and is consistently expressed at a high level in AML blast cells. PI3K can play a selective role in the amplification of phosphatidylinositol (3,4,5) trisphosphate (PIP3) levels that leads to neutrophil polarization, and regulates directional migration, but not random locomotion. The PI3K signaling pathway is involved in immune responses relevant to the pathogenesis of rheumatoid arthritis and other inflammatory diseases.

Specifications
Specifications
Accession Number | O00329, P27986 |
Concentration | See Label |
For Use With (Application) | Kinase Assay |
Formulation | 50 mM sodium phosphate with 0.1 mM PMSF, 0.25 mM DTT, 150 mM Imidazole, 25% glycerol, 300 mM NaCl and no preservative; pH 7 |
Gene ID (Entrez) | 5293, 5295 |
Molecular Weight (g/mol) | 84.7-120.6 kDa |
Name | Human PIK3CD/PIK3R1 (p110 delta/p85 alpha), His Tag |
Quantity | 100 μg |
Gene Alias | PIK3CD; PIK3R1 |
Common Name | PIK3CD/PIK3R1 |
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