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TMP21 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Brand: Proteintech 15199-1-AP-150UL
Additional Details : Weight : 0.00010kg
Description
TMP21 is a ubiquitously expressed protein that is involved in vesicular targeting and protein transport. More recent experiments have shown that it is also a component in the presenilin complex and modulates the -gamma-secretase but not the epsilon-secretase cleavage activity of the amyloid precursor protein. The presenilin complex is composed of the proteins APH1, nicastrin, and PEN2 in addition to presenilin-1. Together, these proteins cleave the amyloid precursor protein at what is known as the -gamma- and epsilon-sites and can lead to the accumulation of the Abeta cleavage product that is associated with Alzheimer′s disease. Co-immunoprecipitation experiments using antibodies against these proteins also yielded TMP21 indicating that TMP21 may play a role in the regulation of this complex. Suppression of TMP21 expression by siRNA in transfected cells caused increased -gamma-secretase activity but not epsilon-secretase activity, and increased Abeta production, demonstrating that TMP21 can modulate -gamma-secretase activity.Specifications
TMP21 | |
Polyclonal | |
Unconjugated | |
TMED10 | |
P24(DELTA), p24delta, S31I125, S31III125, TMED10, Tmp 21 I, TMP21, Transmembrane protein Tmp21 | |
Rabbit | |
Antigen Affinity Chromatography | |
RUO | |
10972, 68581, 84599 | |
-20°C | |
Liquid |
Western Blot, Immunohistochemistry (Paraffin), Immunofluorescence, Immunocytochemistry | |
0.19 mg/mL | |
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3 | |
P49755, Q63584, Q9D1D4 | |
Tmed10 | |
TMP21 Fusion Protein Ag7347 | |
150 μL | |
Primary | |
Rat, Mouse, Human | |
Antibody | |
IgG |