
Crosslinking Reagents
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Thermo Scientific™ Sulfo-SMCC (sulfosuccinimidyl 4-(N-maleimidomethyl)cyclohexane-1-carboxylate), No-Weigh™ Format
Crosslink amines to sulfhydryls with this mid-length, water-soluble crosslinker made of NHS-ester and maleimide groups at ends of a cyclohexane-containing, 8-atom spacer arm.

Shipping Condition | Ambient |
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Content And Storage | Upon receipt store desiccated at -20°C. |
Description | Sulfo-SMCC |
Cleavable | No |
Water Soluble | Yes |
Molecular Weight (g/mol) | 436.37 |
Solubility | Water |
Labeling Method | Chemical Labeling |
Crosslinker Type | Heterobifunctional |
Chemical Reactivity | Amine-Sulfhydryl |
Cell Permeability | No |
Format | Standard, Single-use, Premium-grade |
Product Type | Crosslinker |
Spacer | Short (<10 AĚŠ) |
Reactive Moiety | Maleimide, Sulfo-NHS Ester |
Spacer Arm Length | 8.3 AĚŠ |
PEGylated | No |
Thermo Scientific™ Sulfo-NHS (N-hydroxysulfosuccinimide), No-Weigh™ Format
Prepare amine-reactive sulfo-NHS-ester crosslinkers or enhance carbodiimide (EDC) conjugation for peptides or proteins using N-hydroxysulfosuccinimide, CAS 106627-54-7.

Molecular Weight (g/mol) | 217.13 |
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Solubility | Water |
PEGylated | No |
Thermo Scientific™ BS3 (bis(sulfosuccinimidyl)suberate)
Crosslink amines to amines with BS3; composed of sulfo-NHS-ester groups separated by an 11.4A, water-soluble spacer arm that is useful for cell-surface protein crosslinking.

Cleavable | No |
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Product Type | Crosslinker |
Molecular Weight (g/mol) | 572.43 |
Solubility | Water |
PEGylated | No |
Thermo Scientific™ DMP (dimethyl pimelimidate)
Crosslink amines to amines with dimethyl pimelimidate (CAS 58537-94-3); composed of imidoester groups and a membrane-permeable, 7-atom spacer arm.

Shipping Condition | Ambient |
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Content And Storage | Upon receipt store desiccated at 4°C. |
Description | DMP |
Cleavable | No |
Water Soluble | Yes |
Form | Powder |
Molecular Weight (g/mol) | 259.17 |
Solubility | Water |
Labeling Method | Chemical Labeling |
Crosslinker Type | Homobifunctional |
Chemical Reactivity | Amine-Amine |
Cell Permeability | Yes |
Format | Standard |
Product Type | Crosslinker |
Spacer | Short (<10 AĚŠ) |
Reactive Moiety | Imidoester |
Spacer Arm Length | 9.2 AĚŠ |
Product Line | Pierce™ |
PEGylated | No |
Thermo Scientific™ Pierce™ Premium Grade Sulfo-NHS (N-hydroxysulfosuccinimide)
Optimize applications where product integrity and risk minimization are paramount with our highest quality formulation of this N-hydroxysuccinimide modification reagent.

Shipping Condition | Ambient |
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Content And Storage | Upon receipt store at 4°C. |
Cleavable | No |
Water Soluble | Yes |
Form | Powder |
Molecular Weight (g/mol) | 217.13 |
Solubility | Water |
Labeling Method | Chemical Labeling |
Crosslinker Type | Heterobifunctional |
Chemical Reactivity | Amine-Carboxyl |
Cell Permeability | No |
Format | Standard, Single-use, Premium-grade |
Product Type | Crosslinker |
Spacer | Short (<10 AĚŠ) |
Reactive Moiety | Carbodiimide |
Product Line | Pierce™ |
PEGylated | No |
Thermo Scientific™ SM(PEG)2 (PEGylated SMCC crosslinker)
Crosslink amines to sulfhydryls with these crosslinkers containing NHS-ester and maleimide groups at ends of water-soluble polyethylene glycol spacer arms (17.6 to 95.2A).
Shipping Condition | Ambient |
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Content And Storage | Upon receipt store desiccated at -20°C. |
Cleavable | No |
Water Soluble | Yes |
Form | Solid |
Molecular Weight (g/mol) | 425.39 |
Solubility | Water |
Labeling Method | Chemical Labeling |
Crosslinker Type | Heterobifunctional |
Chemical Reactivity | Amine-Sulfhydryl |
Cell Permeability | No |
Format | Standard, Single-use |
Product Type | Crosslinker |
Spacer | Medium (10 to 30 AĚŠ) |
Reactive Moiety | Maleimide, NHS Ester |
Spacer Arm Length | 17.6 AĚŠ |
Product Line | Pierce™ |
PEGylated | Yes |
Thermo Scientific™ BM(PEG)3 (1,11-bismaleimido-triethyleneglycol)
Crosslink sulfhydryls to sulfhydryls (cysteine residues) with this long, pegylated, water-soluble crosslinker composed of maleimide groups and 3-unit (17.8A) PEG spacer arm.
Thermo Scientific™ LC-SMCC (succinimidyl 4-(N-maleimidomethyl)cyclohexane-1-carboxy-(6-amidocaproate))
Crosslink amines to sulfhydryls with this long crosslinker composed of NHS-ester and maleimide groups at ends of a stabilizing cyclohexane-containing, 15-atom spacer arm.
Thermo Scientific™ EZ-Link™ Maleimide-PEG4-DBCO
A sulfhydryl reactive heterobifunctional crosslinker which contains a dibenzylcyclooctyne (DBCO) group for copper-free click chemistry applications. The thiol/sulfhdryl reactive maleimide can be used to label a variety of thiol containing moieties such as free cystines in proteins, peptides, or other (bio)molecules.
Shipping Condition | Wet Ice |
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Content And Storage | Upon receipt store desiccated at -20°C. |
Description | Maleimide-PEG4-DBCO |
Cleavable | No |
Water Soluble | No |
Molecular Weight (g/mol) | 647.74 |
Solubility | DMF, DMSO |
Labeling Method | Chemical Labeling |
Crosslinker Type | Heterobifunctional |
Chemical Reactivity | Azide-Sulfhydryl |
Cell Permeability | Not determined |
Format | Standard, Single-use |
Product Type | Crosslinker |
Spacer | Medium (10 to 30 AĚŠ) |
Reactive Moiety | Maleimide, DBCO |
Spacer Arm Length | 29.7 AĚŠ |
Product Line | EZ-Link™ No-Weigh™ |
PEGylated | Yes |
Thermo Scientific™ Mass Spectrometry Cleavable Crosslinkers
Improve sensitivity of mass spectrometry detection of crosslinked proteins with MS-cleavable DSSO and DSBU heterotrifunctional crosslinkers.
Content And Storage | Upon receipt store at 4°C protected from moisture. |
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Cleavable | By CID using MS |
Water Soluble | No |
Form | Powder |
Solubility | DMF, DMSO |
Quantity | 10 x 1 mg |
Labeling Method | Chemical Labeling |
Crosslinker Type | Homobifunctional |
Chemical Reactivity | Amine-Amine |
Cell Permeability | Yes |
Format | Standard, Single-use |
Product Type | Crosslinker |
Spacer | Medium (10 to 30 AĚŠ) |
Reactive Moiety | NHS Ester |
PEGylated | No |
Thermo Scientific™ SM(PEG)12 (PEGylated, long-chain SMCC crosslinker)
Crosslink amines to sulfhydryls with these crosslinkers containing NHS-ester and maleimide groups at ends of water-soluble polyethylene glycol spacer arms (17.6 to 95.2A).
Shipping Condition | Ambient |
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Content And Storage | Upon receipt store desiccated at -20°C. |
Cleavable | No |
Water Soluble | Yes |
Form | Liquid |
Molecular Weight (g/mol) | 865.92 |
Solubility | Water |
Labeling Method | Chemical Labeling |
Crosslinker Type | Heterobifunctional |
Chemical Reactivity | Amine-Sulfhydryl |
Cell Permeability | No |
Format | Standard, Single-use |
Product Type | Crosslinker |
Spacer | Long (>30 AĚŠ) |
Reactive Moiety | Maleimide, NHS Ester |
Spacer Arm Length | 53.4 AĚŠ |
Product Line | Pierce™ |
PEGylated | Yes |
Thermo Scientific™ EZ-Link™ TFP Ester-PEG12-DBCO
A heterobifunctional crosslinker that contains an amine reactive tetrafluorophenyl (TFP) and a dibenzylcyclooctyne (DBCO) with a water solubilizing long PEG12 spacer in between. Use to label any primary amine containing molecule such as a protein to biomolecule with a distantly attached DBCO group.
Thermo Scientific™ SM(PEG)6 (PEGylated, long-chain SMCC crosslinker)
Crosslink amines to sulfhydryls with these crosslinkers containing NHS-ester and maleimide groups at ends of water-soluble polyethylene glycol spacer arms (17.6 to 95.2A).
Thermo Scientific™ EZ-Link™ TFP Ester-PEG4-DBCO
An amine reactive heterobifunctional crosslinker which contains a dibenzylcyclooctyne (DBCO) group for copper-free click chemistry applications. The crosslinker can be used to label a variety of amine containing molecules such as proteins, biomolecules, or small molecules.
Shipping Condition | Wet Ice |
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Content And Storage | Upon receipt store desiccated at -20°C. |
Description | TFP Ester-PEG4-DBCO |
Cleavable | No |
Water Soluble | No |
Molecular Weight (g/mol) | 714.7 |
Solubility | DMF, DMSO |
Labeling Method | Chemical Labeling |
Crosslinker Type | Heterobifunctional |
Chemical Reactivity | Amine-Azide |
Cell Permeability | Not determined |
Format | Standard, Single-use |
Product Type | Crosslinker |
Spacer | Medium (10 to 30 AĚŠ) |
Reactive Moiety | TFP Ester, DBCO |
Spacer Arm Length | 17.9 AĚŠ |
Product Line | EZ-Link™ No-Weigh™ |
PEGylated | Yes |
Thermo Scientific™ Pierce™ Premium Grade EDC (1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride)
Optimize applications where product integrity and risk minimization are paramount with this high-quality formulation of carbodiimide crosslinker.

Content And Storage | Upon receipt store desiccated at -20°C. |
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Cleavable | No |
Water Soluble | Yes |
Molecular Weight (g/mol) | 191.7 |
Solubility | Water |
Labeling Method | Chemical Labeling |
Crosslinker Type | Heterobifunctional |
Chemical Reactivity | Amine-Carboxyl |
Cell Permeability | No |
Format | Standard, Single-use, Premium-grade |
Product Type | Crosslinker |
Spacer | Short (<10 AĚŠ) |
Reactive Moiety | Carbodiimide |
Spacer Arm Length | 0.0 AĚŠ |
Product Line | Pierce™ |
PEGylated | No |